Apisolex Technology is Safe to Use in Parenteral Products

Safe for Parenteral Use

	Test	Results
Systemic toxicity	Tolerability (rats and mice)	Well tolerated at doses as high as 1,500 mg/kg
Systemic toxicity	32-day IV injection 28-day recovery (rats)	No treatment-related side effects detected
Pharmacokinetics	[14C] labelled Apisolex IV dose in male and female rats	- Can be distributed to distant organs without accumulation - Tissue: plasma AUC0-t ratios <1.0

Made under GMP conditions, Apisolex excipient is constituted of amino acid building blocks. It’s biocompatible, biodegradable and tested for safety in parenteral projects.

Apisolex™ Polymer