Pemulen™ Polymeric Emulsifiers

Pemulen polymeric emulsifiers are high molecular weight copolymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol. These pharmaceutical excipients provide effective emulsification properties to form stable oil-in-water emulsions. Pemulen polymer excipients contain both hydrophilic and hydrophobic portions and serve as excellent gel forming polymers, creating a network around suspended oil droplets and providing exceptional emulsion stability, often without the need for additional surfactants.
 
These pharmaceutical excipient emulsifiers are ideal for use in topical drug delivery, transdermal drug delivery, and other mucosal applications, such as ophthalmic drug delivery. Pemulen polymers help create low irritancy creams and lotions, providing optimal aesthetics, feel, and drug penetration into the membrane, as well as efficacious, non-irritating emulsion eye drops. Pemulen acrylic acid polymer excipients also provide viscosity building and high yield value to allow for suspension and stabilization of insoluble particulates.

Product Overview

Pemulen
Polymer
Solvent
System
Product
Type
Viscosity, cP
(1.0 wt% at pH 7.5)1
Suggested Uses
TR-1 NF  Cosolvent1 Copolymer 10,000 - 26,500 Low irritancy emulsions (lotions and creams)
TR-2 NF  Cosolvent1 Copolymer 4,500 - 13,500 Low irritancy emulsions (lotions and creams)

1Colsolvent system made using cyclohexane and ethyl acetate

Typical Product Properties

Typical Properties Pemulen TR-1 NF Polymer Pemulen TR-2 NF Polymer
USP/NF monograph Carbomer Copolymer Type B Carbomer Copolymer Type A 
Typical oil levels Up to 20 - 30% Up to 50%
Typical use level (wt%) 0.20 - 0.40 0.20 - 0.40
pH formulating range 4 - 8 4 - 8
Viscosity (mPa*s) pH 7.3 - 7.8    
  0.2 wt% emulsion 6,500 - 15,500 1,700 - 4,500
  1.0 wt% dispersion 10,000 - 26,500 4,500 - 13,500