Pemulen™ Polymeric Emulsifiers

Pemulen polymeric emulsifiers are high molecular weight copolymers of acrylic acid and C10-C30 alkyl acrylate crosslinked with allyl pentaerythritol. These pharmaceutical excipients provide effective emulsification properties to form stable oil-in-water emulsions. Pemulen polymer excipients contain both hydrophilic and hydrophobic portions and serve as excellent gel forming polymers, creating a network around suspended oil droplets and providing exceptional emulsion stability, often without the need for additional surfactants.


These pharmaceutical excipient emulsifiers are ideal for use in topical drug delivery, transdermal drug delivery, and other mucosal applications, such as ophthalmic drug delivery. Pemulen polymers help create low irritancy creams and lotions, providing optimal aesthetics, feel, and drug penetration into the membrane, as well as efficacious, non-irritating emulsion eye drops. Pemulen acrylic acid polymer excipients also provide viscosity building and high yield value to allow for suspension and stabilization of insoluble particulates.

Product Overview

Viscosity, cP
(1.0 wt% at pH 7.5)1
Suggested Uses
TR-1 NF  Cosolvent1 Copolymer 10,000 - 26,500 Low irritancy emulsions (lotions and creams) and high clarity gels
TR-2 NF  Cosolvent1 Copolymer 4,500 - 13,500 Low irritancy emulsions (lotions and creams), high clarity gels and ionic systems

1Colsolvent system made using cyclohexane and ethyl acetate

Typical Product Properties

Typical Properties Pemulen TR-1 NF Polymer Pemulen TR-2 NF Polymer
Emulsion Stabilization Yes Yes
Oil Loading1 Up to 30% Up to 65 - 80%
Relative Viscosity Medium Low
Yield Value High High
Effective pH Range2 4 - 9 4 - 9
Typical Use Concentration3 0.15 - 0.3% 0.15 - 0.3%

1 With no secondary emulsifiers
2 Higher oil levels typically require lower pH
3 Higher levels may be needed in formulations with high electrolyte content