IID Listed Ingredients

Lubrizol Life Science Health (LLS Health) offers many ingredients listed on the FDA’s inactive ingredient database (IID) that can help improve the performance of topical pharmaceutical formulations. Lubrizol’s Carbopol^® polymers, Noveon^® polycarbophil, and Pemulen™ polymers are well known in the industry for use in enhancing topical products. Lubrizol also offers IID-listed emollients, emulsifiers, and humectants which have a long history of use in over-the-counter and prescription drug products.

Emollients

Emollients are used in topical preparations to impart lubrication, spreading ease, texture, and softening of the skin. They also counter the potentially drying or irritating effects of surfactants on the skin. LLS Health offers IID-listed emollients for topical formulations, including lanolin derivatives and light and medium ester emollients; these emollients offer a variety of benefits. For example, Schercemol™ esters provide excellent sensory properties. Due to their different properties/miscibility, Schercemol™ esters can be formulated with a broad range of drugs and co-excipients, rendering them suitable for different types of formulations. Additionally, some Lubrizol emollients may provide solubilizing properties and/or serve as penetration enhancers. Several are also naturally derived, meaning their renewable carbon index (RCI) is above 0.5. Lubrizol’s IID-listed emollients are used in a variety of marketed products across several dosage forms, including creams, patches, topical solutions, ointments, lotions, wipes, foams, and gels.

Schercemol™ 318 ester – Isopropyl Isostearate
Schercemol™ 1688 ester – Cetearyl Ethylhexanoate
Schercemol™ DIA ester – Diisopropyl Adipate
Schercemol™ LL ester – Lauryl Lactate
Schercemol™ OHS ester – Ethylhexyl Hydroxystearate
Schercemol™ OLO ester – Oleyl Oleate
Glucam™ P-20 distearate emollient – PPG-20 Methyl Glucose Ether Distearate
Vilvanolin™ L-101 lanolin derivative – Mineral Oil and Lanolin Alcohol
Solulan™ 75 lanolin derivative – PEG-75 Lanolin
Solulan™ L-575 lanolin derivative – PEG-75 Lanolin

Emulsifiers

An emulsifier or emulsifying agent is an ingredient that stabilizes an emulsion. An emulsion is a thermodynamically unstable system comprising two or more immiscible liquids, one of which is dispersed in the other liquid. LLS Health emulsifiers are non-ionic oil-in-water emulsifiers and are naturally derived. Due to their non-ionic nature, they are non-irritant, meaning they are particularly preferred for sensitive products. They also serve as structurants and may impart some emolliency to formulations. LLS Health’s IID-listed emulsifiers add value to numerous marketed products encompassing multiple dosage forms, such as creams and lotions.

Promulgen™ D Nonionic emulsifier – Cetearyl Alcohol (and) Ceteareth-20
Promulgen™ G Nonionic emulsifier – Stearyl Alcohol (and) Ceteareth-20
Chemonic OLETH-2 ethoxylated alcohol – Oleth-2
Chemonic™ OE-10 ethoxylated alcohol – Oleth-10
Chemonic™ OE-20 ethoxylated alcohol – Oleth-20
Glucate™ SS emulsifier – Methyl Glucose Sesquistearate
Glucamate™ SSE-20 emulsifier – PEG-20 Methyl Glucose Sesquistearate

Humectants

A humectant is a substance that promotes the retention of moisture on the skin. This increased moisture can increase an active ingredient’s solubility, which can then in turn increase the skin penetration. These ingredients deliver light, satiny after-feel to skin formulations and are effective at reducing the tack of glycerin. There are several creams on the market containing these IID-listed humectants and formulated with a variety of APIs.

Glucam™ E-10 humectant – Methyl Gluceth-10
Glucam™ E-20 humectant – Methyl Gluceth-20

Surfactant Thickeners

Glucamate™ DOE-120 thickener – PEG-120 Methyl Glucose Dioleate
Glucamate™ DOE-120 syrup thickener – PEG-120 Methyl Glucose Dioleate

IID Listed Ingredients & Excipients - Emollients, Emulsifiers, Humectants, & Thickeners