Semisolids, such as a creams, lotions, and ointments, and gels are commonly utilized dosage forms in topical and transdermal drug delivery. Lubrizol has extensive experience with semisolids and gels, offering innovative bioadhesive excipients in this space.

Our Carbopol^® polymers, Pemulen^™ polymeric emulsifiers, and Noveon^® polycarbophil have been used extensively in semisolid and gel commercial applications for over fifty years. These excipients provide critical product attributes, including:

Tailored rheology modification and viscosity control
Ideal aesthetics and feel, for the creation of non-greasy creams, exceptionally clear gels, and other optimal semisolid formulations
Highly efficient thickening capabilities and gel formation at low usage levels in aqueous, hydroalchoholic, and anhydrous systems
Stable and consistent drug dispersion in semisolid emulsions and suspensions
Mucoadhesion properties to improve the bioavailability of active ingredients
Compatible with acidic, basic and neutral drugs
Thermal stability, which allows for versatility in final product sterilization

Lubrizol also offers a wide array of additional inactive ingredients for semisolids, such as humectants, emollients, emulsifiers, and surfactant thickeners that are featured on the FDA’s Inactive Ingredient Database (IID).

Our excipients are manufactured under GMPs in ISO:9001 certified facilities, have established DMFs, and have been extensively tested for biocompatibility and safety.

Technical Solutions

All LLS Health products and services are supported by a knowledgeable Technical Solutions staff and technical centers around the world dedicated to aiding our clients.

Semisolid Excipients - Creams, Lotions, and Gels