Bottle of oral drug tablets

Apinovex™ Polymers - Solubility-Enhancing Excipients for Amorphous Solid Dispersions

Lubrizol’s Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray-dried amorphous solid dispersions (ASDs).

Apinovex polymers enable formulators to enhance the solubility of BCS Class II and IV APIs and develop more efficient oral dosage forms with high, stable drug loading.

Improve your formulations with Apinovex™ polymers

  • High drug loading (up to 80%) via spray drying.
  • Significantly improved drug release profile compared to crystalline APIs.
  • Enables IP protection and 505(b)(2) formulations/lifecycle management.

Simplify your manufacturing with Apinovex™ polymers

  • Designed for spray drying and solvent-based processing.
  • Soluble in water and common pharmaceutical solvents.
  • Produces low viscosity solutions for ease of processing.

Achieve your therapeutic goals with Apinovex™ polymers

  • 2x more drug loading compared to Soluplus® and Affinisol™ HPMC excipients.
  • Up to 10x improvement in dissolution of crystalline APIs.
  • Stable amorphous solid dispersions, even after 6 months under accelerated conditions.
 

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Download our One-Pager

To learn more about how our Apinovex™ excipients can help overcome solubility issues in an oral drug development project, download our one-pager today: